background: invasive ductal carcinoma is the most common type of breast cancer in iran. impaired immune responses occur frequently in cancer patients, but the mechanisms of the induced immune defects remain poorly understood. it is believed that infiltrated immune cells, especially macrophages, may provide help for tumor cell growth and metastasis.   objective: to analyze the status of tumor as...

gastrointestinal (gi) cancers are a significant source of morbidity and mortality in iran, with stomach adenocarcinoma as the most common cancer in men and the second common cancer in women. also, some parts of northern iran have one of the highest incidences of esophageal cancer in the world. multi-disciplinary organ-based joint clinics and tumor boards are a well-recognized necessity for mode...

cancer is still one of the major causes of mortality in both developing and developed countries. at this time, in spite of intensive interventions, a large number of patients have poor prognosis. therefore, the effort for finding new anticancer agents with better efficacy and lesser side effects has continued. according to the traditional recommendations and experimental studies, numerous medic...

background: inhibin is a dimeric glycoprotein that has a depressive effect on the anterior hypophyse secretion. the level of this tumor marker is undetectable in menopause women. in patients with gynecological cancer, especially granulosa and epidermal-type (mucinous), ovarian cancers considerable increase in the serum level of inhibin has been reported. the increased level of inhibin has been ...

cancer stem cells (csc) are the tumor-associated cells existed within tumors or hematological cancers which share characteristics similar to normal stem cells. the common characteristics of a normal stem cell and a csc are their differentiation capacity and self-renewal in tumors. the expression pattern of csc markers differs depending on the type and location of cancers. cd molecules are proba...

recent studies have indicated the profound  anti-tumor activity of artemisinin's compounds,  among  which;  arteether  is an  oil-soluble derivative of  artemisinin with an endoperoxide bridge that can induce apoptosis in tumor cells but not in the normal cells. an experiment was carried out on tumor-bearing balb/c mice to estimate the effects of arteether  on  tumor  growth  and  antitumor  im...

conclusions the recurrence of hyperparathyroid hypercalcemia in htp-jt syndrome after an initial total parathyroidectomy is a well-known condition necessitating careful management, an evaluation of any underlying genetic abnormality, and a family examination. a surgical treatment and surveillance of calcium and pth measurements are necessary to prevent a recurrence. introduction cancer in the p...

stem cell based treatments are being increasingly explored for their possible potential to treat various cancers. mesenchymal stem cells believed to possess anti-tumor potential and are preferred for their properties like immune privileged nature, ability to migrate to the site of tumor and capability for multilineage differentiation. this tumor tropism property of mscs could be utilized to del...

background: alteration in peripheral blood lymphocytes (pbls) is usually investigated to provide an evidence of the host immune responses to tumor antigens. the tumor infiltrating nk cells interact most closely with the tumor cells and more accurately reflect tumor host interactions. objective: to analyze peripheral blood and tumor associated natural killer (nk) cells in patients with breast ca...

this article reviews the recently published data on the diagnosis of cancer with proteomics, including the major proteomics technologies and promising strategies for biomarker discovery and development.  most of the tumor markers are proteins that either numerically increase in response to the alteration of cancer conditions or are produced by cancer cells. however, they are natural compounds o...